![]() One patient with NSCLC harbouring the CLIP1–LTK fusion showed a good clinical response to lorlatinib treatment. Treatment of Ba/F3 cells expressing CLIP1–LTK with lorlatinib, an ALK inhibitor, inhibited CLIP1–LTK kinase activity, suppressed proliferation and induced apoptosis. We show that kinase activity of the CLIP1–LTK fusion protein is constitutively activated and has transformation potential. The CLIP1–LTK fusion was present in 0.4% of NSCLCs and was mutually exclusive with other known oncogenic drivers. Here we identify a novel fusion transcript of CLIP1 and LTK using whole-transcriptome sequencing in a multi-institutional genome screening platform (LC-SCRUM-Asia, UMIN000036871). However, such oncogenic drivers are not found in 25–40% of cases of lung adenocarcinoma, the most common histological subtype of NSCLC 2. Targeted therapies stratified by oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-cell lung cancer (NSCLC) 1. Lung cancer is one of the most aggressive tumour types. Sema couple & right now im shocked beyond belief ☹️ condolonces bro – sorry for ur loss.The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer Met Sindhu Arunraja once at the airport, Such a sweet person. My deepest condolences to bro and his family.Really sorry for your loss.Stay strong brother. stay strong (sic),” tweeted music composer and actor Hiphop Tamizha. Sema couple & right now im shocked beyond belief condolonces bro – sorry for ur loss. “Met Sindhu Arunraja once at the airport, Such a sweet person. ![]() ![]() The celebrities are tweeting messages of condolences to Arunraja Kamaraj. Sindhuja’s untimely death has added to the gloom that has overwhelmed the Tamil film industry owing to the aggressive second wave of the Covid-19. ![]()
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